Glycolysis process activation in preserved red blood cells by nanotechnological treatment of resuspending solutions
نویسندگان
چکیده
Currently, the use of nanotechnology opens up new opportunities to influence processes anaerobic glycolysis and activity hexose monophosphate reactions in preserved erythrocytes. Components containing donor red blood cells on CPDA-1 preservative were examined. Modified solutions 0.9% NaCl with 5% glucose used as resuspending solutions. The treated magnetite nanoparticles (ICNB brand) by Belousov method. amounts 2,3-DPG, ATP, reduced glutathione, glutathione peroxidase determined spectrophotometry. This study possibilities for increasing shelf life functional showed a reliable increase ATP decrease 2,3-DPG peroxidase. It was found that activation less pronounced tests modified physiological saline than solution. On contrary, pentose oxidation cycle prevailed. A comprehensive analysis data obtained indicates membrane-protective effect is due an which ensures redox potential cell equilibrium state. Magnetite (ICNB) change mobility orientation hydrogen protons polarizes aqueous sector erythrocyte microenvironment van der Waals forces, main reason phosphate residue hydrolysis switching intracellular enzymes regulating into active As result, transmembrane metabolism change, energy state erythrocytes changes, are activated. All this has significant impact supply preservation their under storage conditions at 2 6 ºС.
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ژورنال
عنوان ژورنال: Regulatory mechanisms in biosystems
سال: 2023
ISSN: ['2519-8521', '2520-2588']
DOI: https://doi.org/10.15421/022302